“my_config.h” file not found when intall mysql-python on osx 10.8

brew install mysql
brew unlink mysql
brew install mysql-connector-c
sed -i -e 's/libs="$libs -l "/libs="$libs -lmysqlclient -lssl -lcrypto"/g' /usr/local/bin/mysql_config
pip install MySQL-python
brew unlink mysql-connector-c
brew link --overwrite mysql
om2c0de

Works well on macOS High Sierra:

If you haven't already installed mysql: brew install mysql

brew unlink mysql
brew install mysql-connector-c
brew link --overwrite mysql
pip install MySQL-python

please try:

brew install mysql-connector-c 
pip install MySQL-python

My problem was that I was using MAMP's version of mysql and it didn't contain the dev headers. I downloaded the dmg of the official release and had it running in no time.

I used brew to install everything on Mac OS 10.14.2.

The other answers weren't working for me, when inside of a virtual environment (virtualenv) on Mojave. I followed Jofsey's instructions but got errors:

#        define SIZEOF_LONG             4
                    ^
    In file included from _mysql.c:44:
    /usr/local/include/my_config.h:179:9: warning: 'SIZEOF_TIME_T' macro redefined [-Wmacro-redefined]
    #define SIZEOF_TIME_T    8
            ^
    /System/Library/Frameworks/Python.framework/Versions/2.7/include/python2.7/pymacconfig.h:57:17: note: previous definition is here
    #        define SIZEOF_TIME_T           4
                    ^
    2 warnings generated.
    _mysql.c:287:14: warning: implicit conversion loses integer precision: 'Py_ssize_t' (aka 'long') to 'int' [-Wshorten-64-to-32]
                    cmd_argc = PySequence_Size(cmd_args);
                             ~ ^~~~~~~~~~~~~~~~~~~~~~~~~
    _mysql.c:317:12: warning: implicit conversion loses integer precision: 'Py_ssize_t' (aka 'long') to 'int' [-Wshorten-64-to-32]
                    groupc = PySequence_Size(groups);
                           ~ ^~~~~~~~~~~~~~~~~~~~~~~
    _mysql.c:470:14: warning: implicit conversion loses integer precision: 'Py_ssize_t' (aka 'long') to 'int' [-Wshorten-64-to-32]
                            int j, n2=PySequence_Size(fun);
                                   ~~ ^~~~~~~~~~~~~~~~~~~~
    _mysql.c:1127:9: warning: implicit conversion loses integer precision: 'unsigned long' to 'int' [-Wshorten-64-to-32]
                    len = mysql_real_escape_string(&(self->connection), out, in, size);
                        ~ ^~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
    _mysql.c:1129:9: warning: implicit conversion loses integer precision: 'unsigned long' to 'int' [-Wshorten-64-to-32]
                    len = mysql_escape_string(out, in, size);
                        ~ ^~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
    _mysql.c:1168:9: warning: implicit conversion loses integer precision: 'Py_ssize_t' (aka 'long') to 'int' [-Wshorten-64-to-32]
            size = PyString_GET_SIZE(s);
                 ~ ^~~~~~~~~~~~~~~~~~~~
    /System/Library/Frameworks/Python.framework/Versions/2.7/include/python2.7/stringobject.h:92:32: note: expanded from macro 'PyString_GET_SIZE'
    #define PyString_GET_SIZE(op)  Py_SIZE(op)
                                   ^~~~~~~~~~~
    /System/Library/Frameworks/Python.framework/Versions/2.7/include/python2.7/object.h:116:56: note: expanded from macro 'Py_SIZE'
    #define Py_SIZE(ob)             (((PyVarObject*)(ob))->ob_size)
                                     ~~~~~~~~~~~~~~~~~~~~~~^~~~~~~
    _mysql.c:1178:9: warning: implicit conversion loses integer precision: 'unsigned long' to 'int' [-Wshorten-64-to-32]
                    len = mysql_real_escape_string(&(self->connection), out+1, in, size);
                        ~ ^~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
    _mysql.c:1180:9: warning: implicit conversion loses integer precision: 'unsigned long' to 'int' [-Wshorten-64-to-32]
                    len = mysql_escape_string(out+1, in, size);
                        ~ ^~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
    _mysql.c:1274:11: warning: implicit conversion loses integer precision: 'Py_ssize_t' (aka 'long') to 'int' [-Wshorten-64-to-32]
            if ((n = PyObject_Length(o)) == -1) goto error;
                   ~ ^~~~~~~~~~~~~~~~~~
    /System/Library/Frameworks/Python.framework/Versions/2.7/include/python2.7/abstract.h:434:25: note: expanded from macro 'PyObject_Length'
    #define PyObject_Length PyObject_Size
                            ^
    _mysql.c:1466:10: warning: implicit conversion loses integer precision: 'unsigned long' to 'int' [-Wshorten-64-to-32]
                            len = strlen(buf);
                                ~ ^~~~~~~~~~~
    _mysql.c:1468:10: warning: implicit conversion loses integer precision: 'unsigned long' to 'int' [-Wshorten-64-to-32]
                            len = strlen(buf);
                                ~ ^~~~~~~~~~~
    _mysql.c:1504:11: warning: implicit conversion loses integer precision: 'unsigned long' to 'int' [-Wshorten-64-to-32]
                                    len = strlen(buf);
                                        ~ ^~~~~~~~~~~
    _mysql.c:1506:11: warning: implicit conversion loses integer precision: 'unsigned long' to 'int' [-Wshorten-64-to-32]
                                    len = strlen(buf);
                                        ~ ^~~~~~~~~~~
    13 warnings generated.
    cc -bundle -undefined dynamic_lookup -Wl,-F. build/temp.macosx-10.14-intel-2.7/_mysql.o -L/usr/local/Cellar/mysql-connector-c/6.1.11/lib -lmysqlclient -lssl -lcrypto -o build/lib.macosx-10.14-intel-2.7/_mysql.so
    ld: library not found for -lssl
    clang: error: linker command failed with exit code 1 (use -v to see invocation)
    error: command 'cc' failed with exit status 1

So, after I ran those commands, I ran this as the final command and it worked:

sudo pip install MySQL-Python --global-option=build_ext --global-option="-I/usr/local/opt/openssl/include" --global-option="-L/usr/local/opt/openssl/lib"

Edit:

Another solution I found on GitHub, assuming you've already run brew install openssl (which avoids the need for CLI parameters and will prevent future SSL library errors):

export LIBRARY_PATH=$LIBRARY_PATH:/usr/local/opt/openssl/lib/

You can put the above in your ~/.bash_profile file and then run source ~/.bash_profile or if it's a virtual environment, you can find a way to run the export in the virtual environment shell and check the value in the virtual environment CLI with echo $LIBRARY_PATH. Once the $LIBRARY_PATH is set, you won't keep seeing these SSL library errors.

As mentioned before, you need the dev headers for MySQL, which don't come with MAMP by default. Rather than using two instances of MySQL, it's possible to add the headers to the MAMP version. There are good instructions for doing so here: http://dreamconception.com/tech/how-to-install-mysqldb-mysql-python-on-mamp/

Make sure not to just copy-paste all the commands, they're a bit out of date so you'll need to change the version numbers in some of them.

I'm using OS X 10.9 and python 2.7, and everything works.